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KMID : 0371320020630050429
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Journal of the Korean Surgical Society
2002 Volume.63 No. 5 p.429 ~ p.431
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Glycogen-Rich Clear Cell Carcinoma of the Breast
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Lee Yun-Young
Kim Joon-Mi
Kim Sei-Joong
Cho Young-Up
Shin Suk-Hwan
Kim Kyung-Rae
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Abstract
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Glycogen-rich clear cell carcinoma of the breast is a very rare malignancy whose incidence is about 1∼3% of the total breast cancers. Histologic features are usually those of ductal carcinoma, but it contains the cells that is characterized by
the
abundant cytoplasm and centrally-located nuclei. We report a case of glycogen-rich clear cell carcinoma of the breast. The case is a 63-year-old woman with a palpable lump of the right breast. The operation is partial mastectomy with axillary lymph
node
dissection. The tumor consists of round or polygonal cells. The cell membranes are distinct, and the cytoplasm is clear. Most of the nulcei are centrally-located and hyperchromatic. The tumor cells are PAS positive and D-PAS negative.
Immunohistochemically, the tumor cells are positive to the epithelial membrane antigen (EMA), and negative to vimentin, smooth muscle actin, desmin. Estrogen receptors are positive, but progesterone receptors are negative.
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